Efficacy of Donepezil in Early-Stage Alzheimer Disease
نویسندگان
چکیده
منابع مشابه
Efficacy of donepezil in early-stage Alzheimer disease: a randomized placebo-controlled trial.
OBJECTIVE To evaluate the efficacy of donepezil in patients with early-stage Alzheimer disease. DESIGN Multicenter, randomized, double-blind, 24-week, placebo-controlled study that enrolled patients with early-stage Alzheimer disease. Patients were randomized in an approximately 2:1 ratio to donepezil, 5 mg/d, for the first 6 weeks, with a forced escalation to 10 mg/d thereafter (n = 96), or ...
متن کاملCardiac safety of donepezil in elderly patients with Alzheimer disease.
OBJECTIVE Donepezil is a widely used cholinesterase inhibitor for the treatment of Alzheimer's disease (AD), however its cholinergic adverse side effects on the cardiovascular system are still unclear. In this study, we aimed to examine the adverse side effects caused by donepezil on cardiac rhythm and postural blood pressure changes in elderly patients with Alzheimer Disease. METHODS The ECG...
متن کاملCognitive predictors of donepezil therapy response in Alzheimer disease.
OBJECTIVES To examine whether the presence of domain-specific cognitive impairments would predict a response to donepezil medication in patients with mild-to-moderate Alzheimer disease (AD). METHODS The protocol was an open-label study of 30 AD subjects (mean age 74 years; education 11 years; Mini-Mental State Exam (MMSE) 23 of 30) beginning a 6-month course of treatment with donepezil. Globa...
متن کاملDonepezil treatment in ethnically diverse patients with Alzheimer disease.
OBJECTIVE To compare the outcome of donepezil treatment in ethnically diverse Alzheimer disease (AD) patients with ethnically diverse AD patients who did not receive donepezil. METHODS Patients meeting NINCDS-ADRA criteria for probable or possible AD from a consortium of California sites were systematically followed for at least 1 year in this prospective, observational study. Their treatment...
متن کاملMild cognitive impairment represents early-stage Alzheimer disease.
BACKGROUND Mild cognitive impairment (MCI) is considered to be a transitional stage between aging and Alzheimer disease (AD). OBJECTIVE To determine whether MCI represents early-stage AD by examining its natural history and neuropathologic basis. DESIGN A prospective clinical and psychometric study of community-living elderly volunteers, both nondemented and minimally cognitively impaired, ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Archives of Neurology
سال: 2004
ISSN: 0003-9942
DOI: 10.1001/archneur.61.12.1852